30/07/05 Nancy – AS Monaco 0-1 (Kapo)
 
 
06/08/05 AS Monaco - Auxerre 0-2
 
 
14/08/05 Strasbourg – AS Monaco 1-2 (Squillaci, Chevanton)
 
 
20/08/05 Bordeaux – AS Monaco 1-0
 
 
28/08/05 AS Monaco – Lens 0-0
 
 
10/09/05 Lyon – AS Monaco 2-1 (Gigliotti)
 
 
18/09/05 AS Monaco – Rennes 0-2
 
 
21/09/05 Troyes – AS Monaco 1-2 (Adebayor, Givet)
 
 
24/09/05 AS Monaco – Nice 0-0
 
 
02/10/05 Lille – AS Monaco 0-1 (Kapo)
 
 
15/10/05 AS Monaco – Metz 3-0 (Gigliotti, Zikos, Meriem)
 
 
23/10/05 Sochaux – AS Monaco 2-1   (Maicon)
 
 
29/10/05 AS Monaco – Ajaccio 3-0 (Chevanton, Givet, Plasil)
 
 
06/11/05 Paris SG – AS Monaco 0-0
 
 
19/11/05 AS Monaco – Saint-Etienne 1-0 (Meriem)
 
 
27/11/05 Marseille – AS Monaco 2-1 (Meriem)
 
 
03/12/05 AS Monaco – Le Mans 2-0 (Modesto, Sorlin)
 
 
11/12/05 Nantes – AS Monaco 0-0
 
 
18/12/05 AS Monaco – Toulouse 1-0 (Kapo (pen))
 
 
05/01/06 Auxerre – AS Monaco 2-1 (Di Vaio)
 
 
11/01/06 AS Monaco – Strasbourg 1-1 (Kapo)
 
 
14/01/06 AS Monaco – Bordeaux 0-1
 
 
22/01/06 Lens – AS Monaco 1-1 (Gakpé)
 
 
29/01/06 AS Monaco – Lyon reporté
 
 
04/02/06 Rennes – AS Monaco 1-3 (Vieri x2, Veigneau)
 
 
11/02/06 AS Monaco – Troyes 1-1 (Vieri)
 
 
18/02/06 Nice – AS Monaco 2-0
 
 
26/02/06 AS Monaco – Lille 0-1
 
 
04/03/06 Metz – AS Monaco 2-1 (Di Vaio)
 
 
11/03/06 AS Monaco – Sochaux 4-1 (Chevanton, Di Vaio x2, Kapo)
 
 
18/03/06 Ajaccio – AS Monaco 1-0
 
 
26/03/06 AS Monaco – Paris SG 1-1 (Chevanton)
 
 
01/04/06 Saint-Etienne – AS Monaco 1-1 (Chevanton)
 
 
08/04/06 AS Monaco – Marseille 1-0 (Chevanton)
 
 
15/04/06 Le Mans – AS Monaco 0-0
 
 
23/04/06 AS Monaco – Lyon 2-1 (Chevanton, Di Vaio)
 
 
30/04/06 AS Monaco – Nantes 1-1 (Chevanton)
 
 
06/05/06 Toulouse – AS Monaco 3-3 (Gakpé, Dos Santos, Chevanton)
 
 
13/05/06 AS Monaco – Nancy 2-2 (Chevanton, Modesto)